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  • • Benzodiazepine hydrolysis at room temperature in less than 5 minutes
  • • Immediate hydrolysis of Carboxy-THC at room temperature
  • • Greater than 80% hydrolysis of 30,000 ng/mL of codeine-6-b-D-glucuronidase in 15 minutes



  • • Fewer contaminants than other enzymes
  • • Reduce matrix effects
  • • Less interferents



  • • Greater than 93% hydrolysis of buprenorphine and norbuprenorphine in 30 minutes
  • • No 6-MAM to morphine conversion

Product Overview

IMCSzyme®, a genetically modified beta-glucuronidase, is a patent pending enzyme solution mainly used to hydrolyze glucuronides obtained from biological fluids detecting a wide range of drugs. After hydrolysis with IMCSzyme, samples can be analyzed by enzyme immunoassay, mass spectrometry, high performance liquid chromatography and other means.

The accuracy of IMCSzyme has been tested on real patient samples in hundreds of labs. Our product has been featured in poster presentations at AACC, MSACL, SOFT, AAFS, ASMS and published in the Journal of Analytical Toxicology.

Product Specifications

Physical description:                                  Clear aqueous solution
Specific Activity (units*/mL):                  >50,000
Guaranteed shelf life:                                6 months
Storage temperature:                                2 – 8 °C
Sulfatase Activity:                                       None detected†

* One modified Fishman unit will liberate 1 microgram of phenolphthalein from phenolphthalein glucuronide per hour at 25 °C at pH 6.8 (30 minute assay)
† Sulfatase activity measured using para-nitrocatechol sulfate with 10 µg of purified enzyme at pH 6.8, 55 °C (1 hour).



Concentration Purity Comparison

Protein Concentration* Comparison

IMCSzyme® 1.0 mg/mL
Purified Abalone 2.4 mg/mL
Abalone 6.9 mg/mL

2.4 times less protein per volume
*Protein concentration is determined using Bradford reagent with BSA as reference standards.

Get Application and Technical Notes